Scientist , Cell Therapy -FSP
China, Remote 职位编号 R0000041108 类别 Medical Sciences关于这个职位
Summary Of The Role You will own key assays and workflows for CAR design, T-cell engineering, and in vitro functional characterization.
You will partner with project teams to enable data-driven decisions that advance programs from discovery toward translation.
You will help shape study plans, and ensure timely delivery of milestones across functions.
Role & Responsibilities
- Study Design and Execution: Design and run in vitro studies for CAR T candidates; design constructs and characterize engineered cell therapies; develop, execute, and optimize functional assays.
- Data analysis and reporting: Analysis data, generate figures, and prepare reports and slide decks, present results and propose next experiment steps.
- Quality and compliance: Ensure adherence to required training and maintain accurate, complete experimental records.
- Cross-functional collaboration: Align with Pharmacology & Toxicology, CMC, translational science and clinical teams to advance project.
- Team and communication: Clear scientific writing and presentation, mentor colleagues and foster a productive, well-organized lab environment
- Problem-Solving: Track record of trouble shooting models, optimizing protocols, and meeting timelines in a dynamic environment.
Requirements Education: PhD in immunology, cell biology, or related field; or MS with 4+ years demonstrated impact in cell therapy discovery
Skills & Capabilities
- Primary Cell Culture: Proficient in human primary cell isolation, culture, activation, and maintenance.
- Prepare lentiviral vectors and perform transduction; optimize MOI to maximize transduction efficiency; assess vector copy number and integration characteristics; conduct electroporation-based gene edits.
- Flow cytometry: Proficient in panel design, compensation, and gating.
- Functional assays: target killing (luciferase/impedance), cytokines, proliferation/persistence, serial-kill or rechallenge assays; antigen density titration and specificity testing.
- Molecular methods: PCR/qPCR, plasmid prep; amplicon NGS prep for edit verification and transgene integrity.
- Data & Tools: Proficiency with ELN, FlowJo, Snapgene, GraphPad; understanding of assay acceptance criteria and basic statistics.
- Compliance: Practice BSL 2 biosafety, uphold animal ethics (IACUC), maintain awareness of research GxP, and ensure data integrity.
Preferred Experience
- Program Advancement: Progress CAR T candidates from lead optimization to preclinical packages; support method transfer and qualification with Process Development.
- Advanced Modalities: Experience with armored CARs, logic gated CARs.
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